The protein kinase C (PKC) enzymes have long been established as critical for synaptic plasticity. However, it is unknown whether Ca2+-dependent PKC isozymes are activated in dendritic spines ...
Get QuoteProtein kinase C (PKC) enzymes are a family of kinases that mediate signal transduction originating at the cell surface. Most cell membranes can contain functional PKC enzymes. Aberrations in the PKC life cycle may result in cellular damage and dysfunction. For example, some cancerous cells exhibit alterations in PKC activity.
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Get QuoteThe PKC isoforms, including β 27 and α, 28 were reported to be important for maturation of Mtb-containing phagosomes. In bacterial infection, we previously reported that PKCδ is critical for ...
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Get QuoteProtein kinase C (PKC) is a family within the AGC-kinases (cyclic AMP-regulated Kinases, cyclic GMP-regulated kinases, and PKCs). PKCs phosphorylate their substrates at serine or threonine residues. The family of 10 different PKCs can be further subdivided into the subfamilies of classical (PKCα, β1, β2, and γ), novel (PKCδ, ε, η, and ...
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Get QuoteProtein kinase C (PKC) is a family of serine/threonine protein kinases, the activation of which plays an important role in the development of diabetic microvascular complications. The activation of PKC under high-glucose conditions stimulates redox reactions and leads to an accumulation of redox stress. As a result, various types of …
Get QuotePKC, a kinase family, influences many types of cells and contributes to different cell responses. As we have reviewed, the activation of PKC influences …
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Get QuoteProtein kinase C (PKC), a phospholipid-dependent serine/threonine kinase, appears to be involved in the signal transduction response to many hormones and growth factors; there are 11 different PKC isozymes. Because PKC isozymes directly and/or indirectly participate in signal transduction pathways of normal and transformed cells through ...
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Get QuoteThe action of DAG on PKC is direct. The minimal DAG-binding site in PKC is a highly conserved C1 domain or cysteine-rich domain (H-X 12-C-X 2-C-X 13–14-C-X 2-C-X 4-H-X 2-C-X 7-C).Classical and ...
Get QuoteProtein kinase C (PKC)-θ is a serine/threonine kinase with both cytoplasmic and nuclear functions. Nuclear chromatin-associated PKC-θ (nPKC-θ) is increasingly recognized to be pathogenic in cancer, whereas its cytoplasmic signaling is restricted to normal T-cell function. Here we show that nPKC-θ is enriched in circulating tumor cells …
Get QuoteThe protein kinase C (PKC) family comprises a group of highly related enzymes that phosphorylate serine and threonine residues on a large number of proteins. Increased activation of specific PKC ...
Get Quote1. Introduction. Protein kinase C (PKC) is a family of phospholipid-dependent serine/threonine kinases and is classified into three subfamilies based on their structural and activation characteristics: conventional or classic PKC isozymes (cPKCs; α, βI, βII, and γ), novel or non-classic PKC isozymes (nPKCs; δ, ε, η, and θ), and atypical PKC …
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